Norgine New Study Highlights Need to Increase Public Understanding of Important Role of Colonoscopy in Preventing and Diagnosing Gastrointestinal Diseases, Including Colorectal Cancer

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Multimedia News Release
http://ots.de/Qou2Hd
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Amsterdam (ots) -

- Those with no previous experience of colonoscopy were considerably
more nervous about the procedure than those who had already undergone
colonoscopy (74% vs 49%)
- Current lack of public understanding around colonoscopy may be
negatively impacting on number of eligible people attending their
colonoscopy appointment
- Less than half (45%) of those who had not had the procedure knew
that a colonoscopy could prevent colorectal cancer

NORGINE B.V. (Norgine) today published the findings of a public
survey at the European Society of Gastrointestinal Endoscopy (ESGE)
Days in Prague as we celebrate the 50th anniversary of the first
colonoscopy. [1],[2],[3] This important study highlights the need to
increase public understanding of the important role of colonoscopy in
the prevention and diagnosis of gastrointestinal diseases including
colorectal cancer. The survey was conducted across five major
European countries and included both people who had undergone a
colonoscopy and those who have no previous experience with the
procedure.

To view the Multimedia News Release, please click:
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The study findings highlighted the misconceptions and strong
negative associations about colonoscopy amongst those who have had no
previous experience with the procedure. Those with no previous
experience of colonoscopy were considerably more nervous about the
procedure than those who had already undergone colonoscopy (74% vs
49%). This may be one of the reasons why many eligible people do not
attend their colonoscopy appointments each year [4] - a vital
procedure for the prevention and diagnosis of gastrointestinal
diseases, including colorectal cancer. The target population for
colorectal cancer screening in the EU is close to 69,000,000, but
only 14% of the target population is currently being screened.[4]

This study has highlighted the benefit of public education to
increase understanding of the importance of the colonoscopy
procedure, and particularly its important role in preventing
colorectal cancer. Less than half (45%) of those who had not had the
procedure knew that a colonoscopy could prevent colorectal cancer.
Other findings suggested the need to improve patient experience of
the procedure, including bowel preparation and the provision of
relevant information. This may provide an opportunity for healthcare
professionals to further support their patients.

"This survey highlights the lack of information about colonoscopy
in public domain. Clinicians need to provide easily accessible and
clear information about colonoscopy to improve the uptake of bowel
cancer screening program in our fight against colorectal cancer,"
said Professor Pradeep Bhandari, Consultant Gastroenterologist, QA
Hospital, Portsmouth.

In the 50 years since the first colonoscopy, the procedure has
become a crucial tool in the prevention and detection of
gastrointestinal disorders, including colorectal cancer. Despite
significant advances, however, the variation in uptake across Europe
continues to prevent the potential of colonoscopy being fully
realised for patients and health systems.

The survey asked 500 and 2500 people with and without colonoscopy
experience across five main EU countries (UK, Germany, France, Spain
and Italy) about their experience and understanding of
colonoscopy.[1],[2],[3]

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Notes to Editors:
Key findings of the survey include: [1],[2],[3]

- Addressing the impact of the public's negative associations to
colonoscopy: Those who had previously undergone a colonoscopy tend to
be less negative towards the procedure than those with no personal
experience. More specifically:
- They would be less nervous to have a colonoscopy (49% vs. 74%)
- They would be less embarrassed (43% vs. 59%)
- Fewer think having a colonoscopy is painful (25% vs. 40%)
- Fewer would be worried about a colonoscopy being painful (37%
vs. 59%)

- People who had a colonoscopy were often positively surprised about
the experience with the majority (59%) felt it was better than
expected
- There is room for improvement on the colonoscopy experience to
encourage its uptake across Europe:

- Bowel preparation: There is a gap between patient expectations and
clinical reality in the amount of bowel preparation liquid volume
patients had to consume [5]
- Unmet need for information: There is a need to further support the
dialogue between healthcare professionals and patients and also
improve the availability of public information resources to increase
understanding of the procedure on both diagnosis and prevention. In
patients who had never undergone a colonoscopy:
- less than 4 in 10 believe colonoscopy is used for removal of
unusual growth (35%)
- 45% knew a colonoscopy could be used for preventing bowel cancer

About the survey

A quantitative study in the UK, Germany, France, Spain and Italy
to compare selected attitudes in the population who never had a
colonoscopy versus people who have had a colonoscopy in the recent
past. Participants included adults who had never had a colonoscopy
(n=500 per country) and those who had a colonoscopy in the last five
years (n=100 per country). The methodology used online interviews
with closed questions only. The study was conducted by GfK and
supported by Norgine. [1],[2],[3]

About Colorectal Cancer and colonoscopy

Colorectal cancer is the second most common cause of
cancer-related mortality world-wide.[6] Colorectal cancer is largely
preventable, with early detection being associated with a 90% with a
90% 5-year survival rate.[7] Colonoscopy is an effective method for
colorectal cancer screening and has been shown to reduce both the
incidence and mortality of colorectal cancer when applied in the
general population. Inadequate pre-colonoscopy bowel cleansing
reduces the diagnostic accuracy of colonoscopy, particularly for the
detection of smaller lesions and sessile (slightly flattened) polyps.
This may result in repeated procedures, thereby potentially
increasing patient burden, resource requirement and costs and can
possibly delay the initiation of treatment.[8],[9],[10]

About Norgine

Norgine is a leading European specialist pharmaceutical company
with a direct commercial presence in all major European markets.
Norgine specialises in gastroenterology, hepatology, cancer and
supportive care. In 2017, Norgine's total net product sales were EUR
345 million, up 17 per cent.

Norgine employs over 1,000 people across its commercial,
development and manufacturing operations and manages all aspects of
product development, production, marketing, sale and supply.

In 2012, Norgine established a complementary business, Norgine
Ventures, supporting innovative healthcare companies through the
provision of debt-like financing in Europe and the US. For more
information, please visit www.norgineventures.com

NORGINE and the sail logo are trademarks of the Norgine group of
companies.

References

[1] Bhandari P, Amlani B, Radaelli F. ePP31 Public attitudes to
colonoscopy: The purpose of colonoscopy. Presented at ESGE 2019,
Prague. http://ots.de/sAFHRA Last accessed April 2019
[2] Amlani B, Bhandari P, Radaelli F. ePP92 Public attitudes to
colonoscopy: Experience of colonoscopy. Presented at ESGE 2019,
Prague. http://ots.de/gevGR2 Last accessed April 2019
[3] Bhandari P, Amlani B, Radaelli F. OP362 Public attitudes to
colonoscopy: Embarrassment levels and colonoscopy. Presented at ESGE
2019, Prague. http://ots.de/RxnY1E Last accessed April 2019
[4] European Commission, Cancer Screening in the European Union,
Report on the implementation of the Council recommendation on cancer
screening, 2017. http://ots.de/Hbp0Au Last accessed April 2019
[5] Amlani B, Radaelli F, Bhandari P. P0460. Public attitudes to
colonoscopy: How much bowel preparation liquid must be drunk before a
colonoscopy? Presented at United European Gastroenterology (ESGE)
Week 2018 in Vienna, Austria
[6] World Health Organisation. Cancer Fact Sheet
https://www.who.int/news-room/fact-sheets/detail/cancer Last accessed
April 2019
[7] American Cancer Society. Can Colorectal Polyps and Cancer Found
Early? http://ots.de/v9KnSh Last accessed April 2019
[8] Bechtold ML, Mir F, Puli SR et al. Optimizing bowel preparation
for colonoscopy: a guide to enhance quality of visualization. Ann
Gastroenterol 2016; 29: 137 - 146
[9] Brenner H, Stock C, Hoffmeister M. Effect of screening
sigmoidoscopy and screening colonoscopy on colorectal cancer
incidence and mortality: systematic review and meta-analysis of
randomised controlled trials and observational studies. BMJ 2014;
348: g2467
[10] Baxter NN, Warren JL, Barrett MJ et al. Association between
colonoscopy and colorectal cancer mortality in a US cohort according
to site of cancer and colonoscopist specialty. J Clin Oncol 2012; 30:
2664 - 2669 GL/COR/0419/0185, Date of preparation April 2019

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For a further information or an interview with Professor Pradeep
Bhandari, please contact:
Eleni Fistikaki +44 (0)1895826227 or +44 (0)7825-389477, Clara
Bentham +44 (0)1895-826654 or +44 (0)7734-367883, contact@norgine.com

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