euro adhoc: Intercell AG / other / Intercell's therapeutic Hepatitis C T-cell vaccine (IC41) advances to next Phase II clinical trial

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26.09.2006

» Start of a further Phase II clinical trial in chronic Hepatitis C
patients using the optimized route and frequency of administration
identified in the recent optimization study » 50 patients will be
vaccinated with IC41 with the aim to achieve a significant
reduction of viral load » Initial results expected in mid 2007

Vienna (Austria), September 26, 2006 - Intercell AG (VSE; "ICLL")
today announced the start of a Phase II - proof of concept - clinical
trial for its therapeutic Hepatitis C vaccine (IC41).

In this Phase II clinical trial, chronic Hepatitis C patients who
have not received a previous treatment will be vaccinated with
Intercell’s therapeutic Hepatitis C vaccine using an optimized route
and frequency of administration identified in the optimization study
completed earlier this year. Results of this optimization study
indicated that IC41, given in optimized route and schedule, is
considerably more immunogenic and that the T-cell responses were
stronger and significantly more frequent than it has been shown
previously. For the current clinical trial, 50 patients will be
enrolled in Germany, Poland and Romania. The study aims to show
significant reductions of HCV-RNA through IC41 stand-alone therapy.
The vaccination regime used in this Phase II study is expected to
achieve significantly stronger T-cell responses than it was observed
in previous trials. Previous clinical trials showed that T-cell
responses were associated with a clinically meaningful decline of
HCV-RNA. Initial results of this Phase II study are expected in mid
2007.

Furthermore, Intercell is currently conducting a Phase II clinical
trial in 24 patients, testing IC41 in combination with
Interferon/Ribavirin standard therapy. Results from this study are
expected for end-2006. The primary objectives of this study are
safety and the pharmacodynamic interactions of IC41 with standard
therapy. Intercell expects the study will further support the
potential future development of IC41 in combination therapy settings
using the new improved administration scheme of IC41.

"We are following a very straightforward development strategy. By
applying our new application scheme of IC41 in chronic patients, we
hope to obtain results, which will contribute in making our vaccine
approach an attractive element in future Hepatitis C therapies",
states Gerd Zettlmeissl, CEO of Intercell.

end of announcement euro adhoc 26.09.2006 07:02:57
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ots Originaltext: Intercell AG
Im Internet recherchierbar: http://www.presseportal.de

Further inquiry note:
Intercell AG
Mag. Katharina Wieser
Head of Corporate Communications
Tel. +43 1 20620-303
kwieser@intercell.com

Branche: Biotechnology
ISIN: AT0000612601
WKN: A0D8HW
Börsen: Wiener Börse AG / official market