Norgine B.V. Enters Into Exclusive Licence and Distribution Agreements for the Commercialisation of PLENVU® in a Number of Countries in Latin America, Southern Africa, Central and Eastern Europe

Amsterdam (ots/PRNewswire) - - Norgine to receive upfront payments, undisclosed
milestone payments along with double-digit percentage royalties

- Norgine retains full commercial rights to PLENVU® in all unlicensed countries

Norgine B.V. (Norgine), a leading European specialist pharmaceutical company,
today announced a number of deals for the commercialisation of Norgine's product
PLENVU® around the world. Norgine entered into exclusive licence and
distribution agreements with:

- Faes Farma S.A. in Chile, Colombia, Costa Rica, Dominican Republic,
Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua,
Panama and Peru.
- Pharmacare Limited T/A Aspen Pharmacare in the Republic of South
Africa, Lesotho, Eswatini, Botswana and Namibia.
- Swixx Biopharma in Central and Eastern Europe including Bosnia and
Herzegovina, Bulgaria, Croatia, Czech Republic, Hungary, Kosovo,
Montenegro, North Macedonia, Poland, Romania, Serbia, Slovakia, and
Slovenia.

Peter Stein, Chairman and Chief Executive Officer of Norginesaid, "Colonoscopy
plays a critical role in the prevention of gastrointestinal diseases including
colorectal cancer. Through these partnerships with Faes Farma, Aspen Pharmacare
and Swixx Biopharma PLENVU® will be able to help more patients around the
globe."

Gonzalo Lopez, General Manager of Faes Farma commented, "We are pleased to
include PLENVU® in our portfolio and are convinced that it will contribute to
the development and improvement of colonoscopy in Latin America, a region where
our company invests significantly to bring added value treatments to patients.
We hope this collaboration with Norgine will be a first step and new cooperation
opportunities may materialize in the future."

Lorraine Hill, Aspen Pharmacare Group Chief Operating Officer said, "The
agreement completed between Pharmacare Limited, a wholly owned subsidiary of
Aspen Holdings and the Group's primary South African trading company, and
Norgine is a positive extension of our relationship locally. The inclusion of
the PLENVU® brand will supplement our existing portfolio in this therapeutic
area."

Swixx CEO, Jean-Michel Lespinasse noted, "Adding PLENVU® to our gastrointestinal
(GI) portfolio, represents a great opportunity for Swixx, building on our
existing excellent collaboration with Norgine. PLENVU® has the potential to help
improve colonoscopy outcomes, patient experience and adherence."

Following the announcement of Norgine's exclusive licence agreement with Korea
Pharma in January 2019, PLENVU® has now launched in South Korea.

PLENVU® is a lower-volume (1L) polyethylene glycol (PEG) based bowel preparation
for colonoscopy in adults. It is the first lower-volume bowel preparation to
show superior segmental cleansing of the colon vs. standard of care.[1]

PLENVU® is currently available in mainland Europe (except France and Sweden) and
Australia via Norgine, in South Korea via its partner Korea Pharma and in the
USA via its partner Salix Pharmaceuticals.[2] For further information on PLENVU®
in the EU visit www.expertiseincolonoscopy.com/plenvu

Notes to Editors:

About PLENVU®

PLENVU®, Powder for Oral Solution (PEG 3350, Sodium Ascorbate, Sodium Sulfate,
Ascorbic Acid, Sodium Chloride, and Potassium Chloride), is indicated in adults
for bowel cleansing prior to any procedure requiring a clean bowel.

About Colorectal Cancer and colonoscopy

Colorectal cancer is the second most common cause of cancer-related mortality
world-wide.[3] Colorectal cancer is largely preventable, with early detection
being associated with a 90% cure rate.[4] Colonoscopy is an effective method for
colorectal cancer screening and has been shown to reduce both the incidence and
mortality of colorectal cancer when applied in the general population.
Inadequate pre-colonoscopy bowel cleansing reduces the diagnostic accuracy of
colonoscopy, particularly for the detection of smaller lesions and sessile
(slightly flattened) polyps. This may result in repeated procedures, thereby
potentially increasing patient burden, resource requirement and costs and can
possibly delay the initiation of treatment.[5],[6],[7]

About Norgine

Norgine is a leading European specialist pharmaceutical company that has been
bringing transformative medicines to patients for over a century. Our commitment
to transforming people's lives drives everything we do and our European
experience, fully integrated infrastructure and exceptional partnership approach
enables us to quickly apply creative solutions to bring life-changing medicines
to patients that they may not otherwise be able to access. Norgine is proud to
have helped 22 million patients around the world in 2019 and generated EUR419
million in net product sales, a growth of 6% over 2018.

Norgine has a direct presence in 14 European countries, as well as Australia and
New Zealand. We also have a strong global network of partnerships in non-Norgine
markets. We are a flexible and fully integrated pharmaceutical business, with
manufacturing (Hengoed, Wales and Dreux, France), third party supply networks
and significant product development capabilities, in addition to our sales and
marketing infrastructure. This enables us to acquire, develop and commercialise
specialist and innovative products that make a real difference to the lives of
patients around the world.

In 2012, Norgine established Norgine Ventures, a complementary business which
supports innovative healthcare companies through the provision of debt-like
financing in Europe and the US. For more information, please visit
http://www.norgineventures.com/.

NORGINE and the sail logo are trademarks of the Norgine group of companies.

Follow us @norgine

About Faes Farma

Founded in 1933, Faes Farma is a Spanish pharmaceutical company with wide
international experience that researches, produces and markets pharmaceutical
products and raw materials, exporting them to many countries.

The identity of the company is defined by an unwavering search of excellence,
the constant pursuit of a maximum pharmacological quality of all its products
and the consequent effort to always offer highly effective solutions for
patients in selected therapeutic areas among which gastro enterology is one of
the most important for the company, as well as allergy treatments.

Faes Farma operates in many countries, employing more than 1.200 people. Its
headquarters, manufacturing and R&D centre are located in Leioa, (Bizkaia). Faes
Farma also has facilities in Madrid and subsidiaries in Portugal, Laboratorios
Vitoria, in Barcelona, Diafarm Laboratories and also in Italy, France, Chile,
México, Colombia, Peru, Ecuador and Nigeria.

About Aspen

Aspen is a leading global player in specialty, branded and generic
pharmaceuticals with an extensive basket of products that provide treatment for
a broad spectrum of acute and chronic conditions experienced through all stages
of life.

With an acknowledged presence of nearly 2 decades in the pharmaceutical sector,
Aspen remains committed to its core values of providing quality and effective
healthcare solutions to millions of patients in more than 150 countries, with
its core focus being in the Thrombosis, Anaesthetic and High Potency & Cytotoxic
therapeutic categories.

Aspen has a strong presence in both emerging and developed countries. Its
emerging market footprint includes Sub-Saharan Africa, Latin America, China,
South East Asia, Eastern Europe and the Commonwealth of Independent States,
comprising Russia and the former Soviet Republics. It is also a leading
pharmaceutical company in developed countries including Australia and most
notably in Western Europe.

Aspen operates with an established business presence in approximately 50
countries spanning 6 continents and employs more than 10,000 people. The Group
operates 26 manufacturing facilities across 18 sites. Aspen holds international
manufacturing approvals from some of the most stringent global regulatory
agencies including the FDA, TGA and EMA. Aspen's manufacturing capabilities are
scalable to demand and cover a wide variety of product-types including oral
solid dose, liquids, semi-solids, steriles, biologicals, APIs and infant
nutritionals.

With a market capitalisation of approximately $10 billion, Aspen is the largest
pharmaceutical company listed on the JSE Limited (share code: APN) and ranks
amongst the top 20 listed companies on this exchange. For more information
visit: http://www.aspenpharma.com/

About Swixx BioPharma AG

Swixx now operates fully-owned subsidiaries across Central and Eastern Europe,
offering coverage from Moscow to Prague and from Tallinn to Sofia. Net sales in
2019 were 143 million Euros and in 2020 should reach 225 million Euros.
Established in 2014, Swixx has gathered outstanding specialty pharmaceutical,
rare disease, medical device and OTC / consumer healthcare talent under one
roof. The company specializes in representing research-based pharmaceutical,
biotech, orphan, medical equipment and self-care brands. For more info about
Swixx, please visit: www.swixxbiopharma.com

References

[1] Repici A., Amlani B., Uebel P., Schreiber S. Superior high-quality colon
cleansing with 1L NER1006 versus sodium picosulfate + magnesium citrate, 2L
polyethylene glycol + ascorbate, or oral sulfate solution: Post hoc pooled
analysis of three randomised phase 3 clinical trials. #P0159. Monday 22 October.
12:30 - 13:30 CET. UEGW 2018

[2] In Austria, Spain and the Netherlands it is known as PLEINVUE® rather than
PLENVU® March 2018. Available at:
https://www.medicines.org.uk/emc/medicine/31722. Accessed June 2018.

[3]World Health Organisation.
https://www.who.int/news-room/fact-sheets/detail/cancerLast accessed February
2020

[4] American Cancer Society. https://www.cancer.org/cancer/colon-rectal-cancer/d
etection-diagnosis-staging/detection.html Last accessed February 2020

[5] Bechtold ML, Mir F, Puli SR et al. Optimizing bowel preparation for
colonoscopy: a guide to enhance quality of visualization. Ann Gastroenterol
2016; 29: 137 - 146

[6] Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and
screening colonoscopy on colorectal cancer incidence and mortality: systematic
review and meta-analysis of randomised controlled trials and observational
studies. BMJ 2014; 348: g2467

[7] Baxter NN, Warren JL, Barrett MJ et al. Association between colonoscopy and
colorectal cancer mortality in a US cohort according to site of cancer and
colonoscopist specialty. J Clin Oncol 2012; 30: 2664 - 2669

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Contact:

Clara Bentham +44 (0)1895-826654 or +44 (0)7734-367883

Eleni Fistikaki +44 (0)1895-826227 or +44 (0)7825-389477

contact@norgine.com

www.norgine.com

Media contacts for Faes Farma: Soraya Gonzalez
accionistas@faesfarma.com

Media contacts for Aspen: Shauneen Beukes
sbeukes@aspenpharma.com

Media contacts for Swixx: Maja Boskovic. +381-11-4426-321
Maja.Boskovic@swixxbiopharma.com

Additional content: https://www.presseportal.de/pm/80824/4518142
OTS: Norgine

Original-Content von: Norgine, übermittelt durch news aktuell