Hyglos GmbH - New Reliable and Sensitive Method for Direct Endotoxin Detection

Munich, Germany (ots) - Hyglos GmbH introduces a ground-breaking
solution for pharmaceutical and biotechnological endotoxin-testing
based on its proprietary phage-ligand technology.

Bacterial endotoxin technology that uses bacteriophage-derived
components has the potential to efficiently detect
lipopolysaccharides (LPS) contaminations in undiluted samples with
reliable results. Initial data on the new approach will be presented
at this year's analytica in Munich by the German biotech company
Hyglos GmbH.

"Our ELISA-based technology uses a bacteriophage protein for a
specific and reliable endotoxin determination", states Dr. Ingrid
Wanninger, Vice President of Hyglos. "Having gained extensive
experience in the endotoxin removal segment with our EndoTrap®
portfolio, the development of a completely new detection system was a
logical step. The Hyglos assay delivers comparable results to LAL and
overcomes limitations of the commonly used methods, for example the
need for substantial dilution to reduce the effect of interfering
factors".

According to the Hyglos assay format the LPS from the sample is
specifically bound to the micro well. Potentially interfering
components from the matrix are removed by a washing step. By doing
this, the subsequent detection is undisturbed allowing a reliable
quantification. Validation studies of the new method are planned to
begin in the second half of this year.

Bacteriophage-based endotoxin detection at a glance:

- Sensitivity comparable to LAL assay
- Low matrix effects due to integrated washing step
- Robust assay with excellent reproducibility
- High reliability enables lower cost per determination

At analytica 2010 (March 23 - 26, Munich) Hyglos will be
presenting its innovative solutions for R&D and pharmaceutical
in-process control testing in Hall A3, booth 261/360. The focus at
this year's show will be on endotoxin detection and removal, protein
services and rapid testing for food microbiology.

This press information is also available at
http://www.hyglos.de/news .

About Hyglos GmbH

Hyglos GmbH was founded in 2009 as the follow-up company of former
Profos AG. Hyglos' core competency is to exploit the principles of
bacteriophage biology and the expert use of the proprietary
phage-ligand technology for research, diagnostic and pharmaceutical
applications.

Originaltext: Hyglos GmbH
digital press kits: http://www.presseportal.de/pm/79075
press kits via RSS: http://www.presseportal.de/rss/pm_79075.rss2

Contact:
Hyglos GmbH
Karolina Heed
Josef-Engert-Str. 11
D-93053 Regensburg
Tel.: +49 (0) 941-942620
Fax: +49 (0) 941-9426220
email: karolina.heed@hyglos.de